Aerobic and Anaerobic Processes
Aerobic respiration is the most efficient way to extract energy from glucose. After glycolysis, pyruvic acid enters the mitochondria where the citric acid cycle (also called the Krebs cycle) breaks it down further, releasing carbon dioxide and creating electron carriers (NADH and FADH₂).
These electron carriers then enter the electron transport chain located in the cristae (folds) of the mitochondria. This is where most ATP is generated—about 32 molecules per glucose! The process ends when hydrogen combines with oxygen to form water.
When oxygen isn't available, cells can still produce some energy through anaerobic fermentation. In your muscle cells, this creates lactic acid, which causes the burning sensation during intense exercise. In yeast cells, fermentation produces alcohol and carbon dioxide (which is how bread rises and beer is made).
Quick Tip: During vigorous exercise, if your muscles can't get enough oxygen, they switch to lactic acid fermentation. This allows continued ATP production but is much less efficient and leads to muscle fatigue.