The Period 5 APUSH era marked significant territorial expansion and political tensions leading to the Civil War. Manifest Destiny APUSH significance centered on America's westward expansion, culminating in the Mexican-American War APUSH and subsequent territorial acquisitions. Key developments included the Missouri Compromise, Kansas-Nebraska Act, and Compromise of 1850, which attempted to address sectional conflicts over slavery.
• The period witnessed dramatic territorial growth through the Mexican Cession and Gadsden Purchase
• Political tensions escalated through events like Bleeding Kansas and the rise of the Republican Party
• Reform movements emerged addressing social issues including abolition and women's rights
• The era concluded with the Civil War and subsequent Reconstruction period
• Key legislation and compromises attempted to balance slave and free state interests